1 Read eBook for: cardiac mechanotransduction [PDF]

Cardiac Mechanotransduction

Cardiac Mechanotransduction PDF

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Author: Matti Weckström
Publisher: Springer Science & Business Media
ISBN: 9780387488684
Size: 19.32 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 159
View: 2306


This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.

Mechanotransduction

Mechanotransduction PDF

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Author:
Publisher: Academic Press
ISBN: 0123983274
Size: 51.80 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 384
View: 6113


Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Muscle

Muscle PDF

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Author: Joseph Hill
Publisher: Academic Press
ISBN: 012381510X
Size: 38.54 MB
Format: PDF, Mobi
Category :
Languages : en
Pages : 1398
View: 1934



Mechanobiology Emerging Tools And Methods

Mechanobiology  Emerging Tools and Methods PDF

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Author: Sara Baratchi
Publisher: Frontiers Media SA
ISBN: 2889637557
Size: 39.99 MB
Format: PDF, Kindle
Category :
Languages : en
Pages :
View: 505



Mechanosensitive Ion Channels

Mechanosensitive Ion Channels PDF

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Author: Andre Kamkin
Publisher: Springer Science & Business Media
ISBN: 1402064268
Size: 71.12 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 382
View: 2578


This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.

Static Equibiaxial Stretch Mediated Mechanotransduction In Adult Cardiac Fibroblasts

Static Equibiaxial Stretch Mediated Mechanotransduction in Adult Cardiac Fibroblasts PDF

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Author: Sonya Renee Summerour
Publisher:
ISBN:
Size: 51.98 MB
Format: PDF
Category :
Languages : en
Pages : 316
View: 6034



Chronotropic Response Of Cardiac Myocytes To Fluid Shear Stress

Chronotropic Response of Cardiac Myocytes to Fluid Shear Stress PDF

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Author: Jeffrey Jeh-min Tsai
Publisher:
ISBN:
Size: 42.32 MB
Format: PDF, ePub, Mobi
Category :
Languages : en
Pages : 142
View: 6076



Brenner And Rector S The Kidney E Book

Brenner and Rector s The Kidney E Book PDF

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Author: Maarten W. Taal
Publisher: Elsevier Health Sciences
ISBN: 1455723045
Size: 58.46 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 3064
View: 7223


Overcome the toughest clinical challenges in nephrology with the new 9th edition of Brenner/Rector’s The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, together with a diverse list of international contributors bring you the latest knowledge and best practices on every front in nephrology worldwide. Brand-new sections on Global Considerations in Nephrology and Pediatric Nephrology, as well as new chapters on recent clinical trials, cardiovascular and renal risk prediction in chronic kidney disease, identification of genetic causes of kidney disease, and many others, keep you at the forefront of this rapidly growing, ever-changing specialty. Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices. Broaden your knowledge base with expert, dependable, comprehensive answers for every stage of your career from the most comprehensive, definitive clinical reference in the field! Prepare for certification or recertification with a review of the basic science that underpins clinical nephrology as well as a comprehensive selection of the most important bibliographical sources in nephrology. Visually grasp and better understand critical information with the aid of over 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making. Get internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors, all of whom are at the top and the cutting edge of your field. A new editorial team headed by Dr. Taal and hand-picked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. Access information quickly thanks to a new, reorganized format and supplemental figures, tables, additional references, and expanded discussions. Keep current with the rapid development of care and research worldwide. A new section, "Global Considerations", focuses on regions outside Europe and North America. Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty. Improve therapy and outcomes for children with renal disease. New to this edition, "Pediatric Nephrology" addresses renal pathologies that usually present in childhood and covers topics such as Maturation of Kidney Structure and Function; Fluid; Electrolyte and Acid-Base Disorders in Children; Diseases of the Kidney and Urinary Tract in Children; Dialysis in Children; and Kidney Transplantation in Children. Stay up to date with all the latest clinical information including recent clinical trials, genetic causes of kidney disease, and cardiovascular and renal risk prediction in chronic kidney disease.

Heart S Vortex

Heart s Vortex PDF

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Author: Ares Pasipoularides
Publisher: PMPH-USA
ISBN: 9781607950332
Size: 34.28 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 927
View: 3359


This outstanding resource provides a comprehensive guide to intracardiac blood flow phenomena and cardiac hemodynamics, including the developmental history, theoretical frameworks, computational fluid dynamics and practical applications for clinical cardiology, cardiac imaging and embryology. It is not a mere compilation of the most up-to-date scientific data and relevant concepts. Rather, it is an integrated educational means to developing pluridisciplinary background, knowledge and understanding. Such understanding allows an appreciation of the crucial, albeit heretofore generally unappreciated, importance of intracardiac blood flow phenomena in a host of multifaceted functional and morphogenetic cardiac adaptations. The book includes over 400 figures, which were prepared by the author and form a vital part of the pedagogy. It is organized in three parts. Part I, Fundamentals of Intracardiac Flows and Their Measurements Part II, Visualization of Intracardiac Blood Flows: Methodologies, Frameworks and Insights Part III contains an Appendix presenting technical aspects of the method of predetermined boundary motion, “PBM,†developed at Duke University by the author and his collaborators

Mechanosensitivity And Mechanotransduction

Mechanosensitivity and Mechanotransduction PDF

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Author: Irina Kiseleva
Publisher: Springer Science & Business Media
ISBN: 9789048198818
Size: 41.70 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 371
View: 7370


This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

The Science And Clinical Application Of Manual Therapy E Book

The Science and Clinical Application of Manual Therapy E Book PDF

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Author: Hollis H. King
Publisher: Elsevier Health Sciences
ISBN: 0702049956
Size: 69.94 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 336
View: 7337


The Science and Clinical Application of Manual Therapy is a multi-disciplinary, international reference book based on work by the top basic science researchers and clinical researchers in the area of Manual Therapy and Manual Medicine (MT/MM). The first book to bring together research on the benefits of MT/MM beyond the known effects on musculoskeletal disorders, it presents evidence of the benefit of MT/MM in treating systemic disorders such as asthma, heart rate dysfunction and GI disturbance. Authored by the leading multidisciplinary basic science and clinical researchers from throughout the world Describes research confirming benefit of MT for musculoskeletal disorders (which helps provide a rational for greater utilization of manual therapy and reimbursement for this healthcare service) Presents the latest findings on the beneficial effect of MT on systemic disorders including asthma, pneumonia, otitis media, heart rate dysfunction and GI disturbance Critically assesses longstanding theoretical models of MT/MM mechanisms with respect to the current understanding of physiological and neurophysiological function Explores the influences of psychological and cortical processes on the effects of MT/MM, including the effect of placebo Uniquely presents research findings from all the manual therapy professions and scientists making the case for the benefits of MT The symposium from which the book was derived was supported by the NIH National Center for Complimentary and Alternative Medicine

Cardiac Engineering

Cardiac Engineering PDF

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Author: Samuel Sideman
Publisher:
ISBN:
Size: 13.25 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 406
View: 3554


This volume concentrates on the analysis of the contributions of micro-scale elements on the structure and function of the cardiovascular system through pursuit of the characteristics of the basic elements: cells, organelles, genes, molecules, and ions, as well as the control mechanisms affecting the various interactions and functions. The general goals of this volume are to 1. foster interdisciplinary interaction among leading world scientists and clinical cardiologists in order to identify missing knowledge and catalyze new research ideas; 2. relate basic microscale, molecular, and subcellular phenomena to global clinically manifested cardiac performance; 3. apply conceptual modeling and quantitative analysis to better explore, describe, and understand cardiac physiology; 4. interpret available clinical data and design new revealing experiments; and 5. enhance international cooperation in the search for the secrets of life and their implications in cardiac pathophysiology.

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